What: On December 23, 2025, the Department of Health and Human Services (HHS) published a Request for Information (RFI) seeking broad public comment on what HHS can do to accelerate the adoption and use of Artificial Intelligence (AI) as part of clinical care. HHS seeks feedback that will inform agency-wide AI use of three different areas: regulation, reimbursement, and research & development.
Why: HHS’s RFI solicits public input on the most effective applications that will support the rapid adoption and use of AI in clinical care, to foster public trust and confidence in modern technology solutions, to reduce uncertainty that impedes AI innovation, and to align federal incentives so that AI is deployed in ways that enhance productivity, reduce burden, lower health care costs, and improve health outcomes for patients, caregivers, and communities. In addition to the general requests for information regarding AI regulation, reimbursement, and research & development, HHS seeks specific input, including but not limited to:
- The biggest barriers to private sector innovation in AI in health care and clinical care.
- Best practices for HHS to best support private sector activities. These include HHS regulations, policies, or programs to promote and incentivize effective development or use of AI in clinical care.
- The most influential entities within health care organizations that foster the use and development of AI in clinical care and the primary administrative hurdles to the adoption of AI in clinical care.
Action: HHS’s Request for Information is published in the Federal Register. Comments are due to HHS on or before February 23, 2026.
REQUEST FOR INFORMATION: Accelerating the Adoption and Use of Artificial Intelligence as Part of Clinical Care
CONTACT: Will Purcell or David Mullis
EMAIL: will.purcell@sba.gov or david.mullis@sba.gov
TOPIC(S): Regulatory Alerts
TAG(S): HHS